Erythrocyte indices in creutzfeldt–jakob disease predict survival time

Background Creutzfeldt–Jakob disease (CJD) is a devastating neurodegenerative caused by propagation of abnormally folded prion proteins (PrPSc). Some fluid biomarkers have been reported to be associated with duration in CJD. Based on studies which found that protein (PrPC) played role erythrocytic hematopoiesis, we evaluated the association between peripheral red blood cell indices and survival time Method We retrospectively collected data indices, including (RBC) count, hemoglobin (Hb), hematocrit (HCT), mean corpuscular volume (MCV), (MCH), concentration (MCHC), distribution width (RDW), from 125 CJD patients. Cox proportional hazard models were generated determine whether correlated patients Result Of included participants, 70 (56%) male, age at diagnosis (SD) was 60.3 (9.5) years. Hemoglobin levels (hazard ratio 1.710, 95% CI 1.124-2.600, p = 0.012) HCT 1.689, 1.112-2.565, 0.014) significantly after controlling for sex, age, Barthel Index. Red MCV, MCH, MCHC, RDW not before or adjusting covariates. Conclusion Our study Hb These results may inform evaluation mechanisms interaction indicate potential prognostic biomarkers.